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Prolactin adenomas

This was a retrospective, descriptive and analytical study of 77 cases of prolactinomas collected and followed up in the endocrinology and diabetology department of the Hedi Chaker University Hospital of Sfax between 2000 and 2017. Different clinical, paraclinical and therapeutic characteristics were described. Our patients were divided into 3 groups according to the size of their prolactinomas. Statistical correlations were sought between tumor size and clinical and biological parameters. Prolactin adenoma was studied in pregnant women, elderly subjects and when its discovery was incidental.The average age of our patients was 38.3±14.2 years. The average age of our patients was 38.3±14.2 years. 51 (66.2%) were women and 26 (33.7%) were men. The diagnostic latency was 47.37 months on average. The pituitary tumor syndrome was a circumstance of discovery observed in 62.3% of cases. The endocrine syndrome of hyperprolactinemia was manifested in women by menstrual cycle disorders (78.4%) and galactorrhea (70.5%). In men, the clinical picture was dominated by erectile dysfunction (42.3%) and/or decreased libido (34.6%). The anteropituitary insufficiency syndrome was observed in 75.3% of cases. The number of anteropituitary deficits was significantly correlated with the tumor size. Comparing the three groups, we noted that age, CDD, metabolic parameters, hypopituitarism and pituitary extensions on imaging were significantly different

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Prolactin adenomas

Este foi um estudo retrospectivo, descritivo e analítico de 77 casos de prolactinoma coletados e acompanhados no departamento de endocrinologia e diabetologia do Hospital Universitário Hedi Chaker em Sfax entre 2000 e 2017. Foram descritas diferentes características clínicas, paraclínicas e terapêuticas. Nossos pacientes foram divididos em 3 grupos de acordo com o tamanho de seus prolactinomas. Foram procuradas correlações estatísticas entre o tamanho do tumor e os parâmetros clínicos e biológicos. O adenoma de prolactina foi estudado em gestantes, idosos e quando sua descoberta foi incidental, a idade média de nossos pacientes foi de 38,3±14,2 anos. A idade média dos nossos pacientes foi de 38,3±14,2 anos. 51 (66,2%) eram mulheres e 26 (33,7%) eram homens. A latência média de diagnóstico foi de 47,37 meses. A síndrome do tumor hipofisário foi uma circunstância de descoberta em 62,3% dos casos. A síndrome endócrina da hiperprolactinemia manifestou-se nas mulheres por distúrbios do ciclo menstrual (78,4%) e galactorreia (70,5%). Nos homens, o quadro clínico foi dominado pela disfunção erétil (42,3%) e/ou diminuição da libido (34,6%). A síndrome da insuficiência anteropituitária foi observada em 75,3% dos casos. O número de défices hipofisários estava significativamente correlacionado com o tamanho do tumor. Comparando os três grupos, notamos que idade, CDD, parâmetros metabólicos, hipopituitarismo e extensões pituitárias na imagem foram significativamente diferentes

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Adenomas de prolactina

Se trata de un estudio retrospectivo, descriptivo y analítico de 77 casos de prolactinoma recogidos y seguidos en el servicio de endocrinología y diabetología del Hospital Universitario Hedi Chaker de Sfax entre 2000 y 2017. Se describieron diferentes características clínicas, paraclínicas y terapéuticas. Nuestros pacientes fueron divididos en 3 grupos según el tamaño de sus prolactinomas. Se buscaron correlaciones estadísticas entre el tamaño del tumor y los parámetros clínicos y biológicos. El adenoma de prolactina se estudió en mujeres embarazadas, sujetos de edad avanzada y cuando su descubrimiento fue incidental.La edad media de nuestros pacientes fue de 38,3±14,2 años. La edad media de nuestros pacientes fue de 38,3±14,2 años. 51 (66,2%) eran mujeres y 26 (33,7%) eran hombres. La media de latencia diagnóstica fue de 47,37 meses. El síndrome tumoral hipofisario fue una circunstancia de descubrimiento en el 62,3% de los casos. El síndrome endocrino de la hiperprolactinemia se manifestó en las mujeres por trastornos del ciclo menstrual (78,4%) y galactorrea (70,5%). En los hombres, el cuadro clínico estaba dominado por la disfunción eréctil (42,3%) y/o la disminución de la libido (34,6%). El síndrome de insuficiencia anteropituitaria se observó en el 75,3% de los casos. El número de déficits hipofisarios estaba significativamente correlacionado con el tamaño del tumor. Al comparar los tres grupos, observamos que la edad, la DDC, los parámetros metabólicos, el hipopituitarismo y las extensiones hipofisarias en las imágenes eran significativamente diferentes

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The Pituitary

The Pituitary, Fifth Edition continues the tradition of a cogent blend of basic science and clinical medicine. The comprehensive text written by expert pituitary scholars is devoted to the pathogenesis, diagnosis and treatment of pituitary disorders. The new fifth edition has been extensively revised to reflect the most recent data on new research advances in tumorigenesis and new therapeutic approaches for pituitary tumors, particularly in acromegaly and Cushing disease. Notably, new chapters devoted to the Pituitary-Immune Interface and Pituitary Radiotherapy have been included, along with a chapter on Aggressive Pituitary Adenomas developed to align with the WHOs Classification of Pituitary Tumors. Furthermore, new authors have been invited, ensuring a fresh perspective on critical issues in the field. This extensive body of knowledge is useful for students, trainees, physicians, and scientists who need to understand critical pituitary functions and how to care for patients with pituitary disorders.

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Price: 213.99 EUR excl. shipping